Synchronization Algorithms for FBMC Systems

Filter bank multicarrier (FBMC) systems, such as FMT and OFDM/OQAM systems, can provide reduced sensitivity to narrowband interference, high flexibility to allocate group of subchannels to different users and a high spectral containment. On the other hand, as all the multicarrier modulation schemes, one of their major drawbacks is their sensitivity to CFO and symbol timing errors. In this thesis the problem of CFO and symbol timing synchronization is examined and new data-aided and blind estimation techniques are proposed. Specifically, it is presented a new joint symbol timing and CFO synchronization algorithm based on the LS approach. Moreover, the joint ML phase offset, CFO and symbol timing estimator for a multiple access OFDM/OQAM system is considered. It is also proposed a closed-form CFO estimator based on the best linear unbiased estimation principle for FMT systems. Blind CFO estimators based on the ML principle for low SNR are also considered and, moreover, a closed-form CFO synchronization algorithm based on the LS method is derived. Finally, it is also proposed, under the assumption of low SNR, the joint ML symbol timing and phase offset estimator

Joint Symbol Timing and CFO Estimation for OFDM/OQAM Systems in Multipath Channels

The problem of data-aided synchronization for orthogonal frequency division multiplexing (OFDM) systems based on offset quadrature amplitude modulation (OQAM) in multipath channels is considered. In particular, the joint maximum-likelihood (ML) estimator for carrier-frequency offset (CFO), amplitudes, phases, and delays, exploiting a short known preamble, is derived. The ML estimators for phases and amplitudes are in closed form. Moreover, under the assumption that the CFO is sufficiently small, a closed form approximate ML (AML) CFO estimator is obtained. By exploiting the obtained closed form solutions a cost function whose peaks provide an estimate of the delays is derived. In particular, the symbol timing (i.e., the delay of the first multipath component) is obtained by considering the smallest estimated delay. The performance of the proposed joint AML estimator is assessed via computer simulations and compared with that achieved by the joint AML estimator designed for AWGN channel and that achieved by a previously derived joint estimator for OFDM systems

Myo-inositol may prevent gestational diabetes onset in overweight women: a randomized, controlled trial

Objective: To evaluate whether myo-inositol supplementation may reduce gestational diabetes mellitus (GDM) rate in overweight women. Methods: In an open-label, randomized trial, myo-inositol (2 g plus 200 μg folic acid twice a day) or placebo (200 μg folic acid twice a day) was administered from the first trimester to delivery in pregnant overweight non-obese women (pre-pregnancy body mass index ≥ 25 and < 30 kg/m2). The primary outcome was the incidence of GDM. Results: From January 2012 to December 2014, 220 pregnant women were randomized at two Italian University hospitals, 110 to myo-inositol and 110 to placebo. The incidence of GDM was significantly lower in the myo-inositol group compared to the placebo group (11.6% versus 27.4%, respectively, p = 0.004). Myo-inositol treatment was associated with a 67% risk reduction of developing GDM (OR 0.33; 95% CI 0.15–0.70). Conclusions: Myo-inositol supplementation, administered since early pregnancy, reduces GDM incidence in overweight non-obese women

Depressive-like behavior is paired to monoaminergic alteration in a murine model of Alzheimer's disease

BACKGROUND: Neuropsychiatric signs are critical in primary caregiving of Alzheimer patients and have not yet been fully investigated in murine models. METHODS: 18-month-old 3×Tg-AD male mice and their wild-type male littermates (non-Tg) were used. The open field test and the elevated plus maze test were used to evaluate anxiety-like behaviors, whereas the Porsolt forced swim test, the tail suspension test, and the sucrose preference test for antidepressant/depression-coping behaviors. Neurochemical study was conducted by microdialysis in freely-moving mice, analyzing the basal and K(+)-stimulated monoamine output in the frontal cortex and ventral hippocampus. Moreover by immunohistochemistry, we analysed the expression of Tyrosin hydroxylase and Tryptophan hydroxylase, which play a key role in the synthesis of monoamines. RESULTS: Aged 3×Tg-AD mice exhibited a higher duration of immobility in the forced swim and tail suspension tests (predictors of depression-like behavior) which was not attenuated by a noradrenaline reuptake inhibitor, desipramine. In the sucrose preference test, 3×Tg-AD mice showed a significantly lower sucrose preference compared to the non-Tg group, without any difference in total fluid intake. In contrast, the motor functions and anxiety-related emotional responses of 3×Tg-AD mice were normal, as detected by the open-field and elevated plus-maze tests. To strengthen these results, we then evaluated the monoaminergic neurotransmissions by in vivo microdialysis and immunohistochemistry. In particular, with the exception of the basal hippocampal dopamine levels, 3×Tg-AD mice exhibited a lower basal extracellular output of amines in the frontal cortex and ventral hippocampus and also a decreased extracellular response to K(+) stimulation. Such alterations occur with obvious local amyloid-β and tau pathologies and without gross alterations in the expression of Tyrosin and Tryptophan hydroxylase. CONCLUSIONS: These results suggest that 3×Tg-AD mice exhibit changes in depression-related behavior involving aminergic neurotrasmitters and provide an animal model for investigating AD with depression

MORFEO enters final design phase

MORFEO (Multi-conjugate adaptive Optics Relay For ELT Observations, formerly MAORY), the MCAO system for the ELT, will provide diffraction-limited optical quality to the large field camera MICADO. MORFEO has officially passed the Preliminary Design Review and it is entering the final design phase. We present the current status of the project, with a focus on the adaptive optics system aspects and expected milestones during the next project phase

Effect of the relative shift between the electron density and temperature pedestal position on the pedestal stability in JET-ILW and comparison with JET-C

The electron temperature and density pedestals tend to vary in their relative radial positions, as observed in DIII-D (Beurskens et al 2011 Phys. Plasmas 18 056120) and ASDEX Upgrade (Dunne et al 2017 Plasma Phys. Control. Fusion 59 14017). This so-called relative shift has an impact on the pedestal magnetohydrodynamic (MHD) stability and hence on the pedestal height (Osborne et al 2015 Nucl. Fusion 55 063018). The present work studies the effect of the relative shift on pedestal stability of JET ITER-like wall (JET-ILW) baseline low triangularity (\u3b4) unseeded plasmas, and similar JET-C discharges. As shown in this paper, the increase of the pedestal relative shift is correlated with the reduction of the normalized pressure gradient, therefore playing a strong role in pedestal stability. Furthermore, JET-ILW tends to have a larger relative shift compared to JET carbon wall (JET-C), suggesting a possible role of the plasma facing materials in affecting the density profile location. Experimental results are then compared with stability analysis performed in terms of the peeling-ballooning model and with pedestal predictive model EUROPED (Saarelma et al 2017 Plasma Phys. Control. Fusion). Stability analysis is consistent with the experimental findings, showing an improvement of the pedestal stability, when the relative shift is reduced. This has been ascribed mainly to the increase of the edge bootstrap current, and to minor effects related to the increase of the pedestal pressure gradient and narrowing of the pedestal pressure width. Pedestal predictive model EUROPED shows a qualitative agreement with experiment, especially for low values of the relative shift

Folati ed osteoporosi

Esistono varie evidenze che sembrano legare folati ed osteoporosi. I folati sono una serie di composti vitaminici del gruppo della vitamina B che sono necessari quali donatori di metile per la trasformazione dell’omocisteina in metionina. Studi osservazionali hanno evidenziato che individui con deficit genetici nel metabolismo dell’omocisteina hanno un maggior rischio di sviluppare osteoporosi e frattura. Ugualmente studi osservazionali hanno evidenziato che elevati livelli di omocisteina si associano ad un maggior rischio di frattura. La presenza di folati è necessaria per la riduzione dei livelli di omocisteina. Gli studi che hanno considerato oltre che i livelli di omocisteina anche i livelli di folati hanno evidenziato come i bassi livelli di folati rappresentino un fattore di rischio maggiore rispetto ai livelli di omocisteina per bassi valori di massa ossea, per la velocità di perdita di massa ossea e per fratture osteoporotiche. I folati sembrano pertanto agire nella prevenzione dell’osteoporosi attraverso meccanismi che sono solo in parte mediati dalla loro capacità di ridurre i livelli di omocisteina. La supplemetazione con folati in individui con precedente ictus ha ridotto il numero successivo di fratture. Ulteriori studi sono necessari per meglio definire quale sia l’effettivo ruolo dei folati nella fisiologia dell’osso e come la supplementazione con folati si collochi tra le stategie preventive della perdita di massa ossea

Data-aided symbol timing and CFO synchronization for filter bank multicarrier systems

In this paper we consider the problem of dataaided joint symbol timing and carrier-frequency offset (CFO) estimation for filter bank-based multicarrier (FBMC) systems. As all multicarrier systems, FBMC systems are very sensitive to synchronization errors, since CFO and symbol timing errors cause interference between successive symbols and adjacent subcarriers which can lead to a severe performance degradation. Therefore, reliable and accurate synchronization algorithms must be designed for these systems. The approach herein presented is based on the deployment of appropriate training sequences. In particular, we propose a new joint symbol timing and CFO synchronization algorithm based on the least squares approach and exploiting the transmission of a training sequence made up of identical parts. The performance of the derived estimators, assessed by computer simulations, is compared with that of two data-aided synchronization algorithms previously proposed in the literature